Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.
Purpose: Dexmedetomidine is an α-adrenoceptor agonist used for perioperative and intensive care sedation. This study develops mechanism-based population pharmacokinetic-pharmacodynamic models for the cardiovascular and central nervous system (CNS) effects of intravenously (IV) and intranasally (IN)...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 71; no. 10; pp. 1197 - 1208 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | equations & formulas research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Oct2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |