Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.

Purpose: Dexmedetomidine is an α-adrenoceptor agonist used for perioperative and intensive care sedation. This study develops mechanism-based population pharmacokinetic-pharmacodynamic models for the cardiovascular and central nervous system (CNS) effects of intravenously (IV) and intranasally (IN)...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 71; no. 10; pp. 1197 - 1208
Main Authors:	Yoo, Heedoo, Iirola, Timo, Vilo, Sanna, Manner, Tuula, Aantaa, Riku, Lahtinen, Maria, Scheinin, Mika, Olkkola, Klaus, Jusko, William
Format:	equations & formulas research tables/charts randomized controlled trial Journal Article
Published:	Springer Nature Oct2015
Online Access:	View this record in EBSCOhost