Structure activity relationship of bergenin, p -hydroxybenzoyl bergenin, 11- O -galloylbergenin as potent antioxidant and urease inhibitor isolated from Bergenia ligulata.
Ethanol extract of the aerial parts ofBergenia ligulatawas subjected to solvent–solvent separation followed by various chromatographic techniques that lead to isolation of bergenine (1),p-hydroxybenzoyl bergenin (2), 11-O-galloylbergenin (3) and methyl gallate (4) as major constituents. Ethyl acetat...
| Publicado en: | Natural Product Research Vol. 29; no. 24; pp. 2291 - 2295 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110071329&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110071329 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Dec2015 vid: 29 iid: 24 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 110071329 10.1080/14786419.2015.1004173 110071329 ppf: 2291 ppct: 4 formats: tig: atl: Structure activity relationship of bergenin, p -hydroxybenzoyl bergenin, 11- O -galloylbergenin as potent antioxidant and urease inhibitor isolated from Bergenia ligulata. aug: au: Sadat, Anwar Uddin, Ghias Alam, M. Ahmad, Ashfaq Siddiqui, Bina Shaheen affil: Institute of Chemical Sciences, University of Peshawar, Peshawar25120, Pakistan sug: ab: Ethanol extract of the aerial parts ofBergenia ligulatawas subjected to solvent–solvent separation followed by various chromatographic techniques that lead to isolation of bergenine (1),p-hydroxybenzoyl bergenin (2), 11-O-galloylbergenin (3) and methyl gallate (4) as major constituents. Ethyl acetate fraction showed a dose-dependent urease inhibitory pattern with IC50value of 54μg/mL. Structures of compounds1and3were established by XRD and2,4by NMR. All these compounds were subjected to DPPH scavenging activity, reducing power assay and urease inhibitory activity. The EC507.45 ± 0.2 μg/mL and 5.39 ± 0.28 μg/mL values in terms of antioxidant and reducing power, respectively, were less for3. Compounds1–3showed moderate to significant urease inhibitory potential with IC5057.1 ± 0.7, IC5048.4 ± 0.3 and 38.6 ± 1.5. Antioxidant activities and urease inhibitory potential were investigated and compound3was found to be the most active. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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