Overview of 'Omics Technologies for Military Occupational Health Surveillance and Medicine.
Systems biology ('omics) technologies are emerging as tools for the comprehensive analysis and monitoring of human health. In order for these tools to be used in military medicine, clinical sampling and biobanking will need to be optimized to be compatible with downstream processing and analysis for...
| Publicado en: | Military Medicine Vol. 180; pp. 34 - 49 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Oxford University Press / USA
2015 Supplement
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110220209&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110220209 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: 2015 Supplement vid: 180 pid: 622 pub: Oxford University Press / USA artinfo: ui: 110220209 110220209 NLM26444891 110220209 10.7205/MILMED-D-15-00050 NLM26444891 110220209 ppf: 34 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Overview of 'Omics Technologies for Military Occupational Health Surveillance and Medicine. aug: au: Bradburne, Christopher Graham, David Kingston, H. M. Brenner, Ruth Pamuku, Matt Carruth, Lucy affil: National Security Systems Biology Center, Asymmetric Operations Sector, Applied Physics Laboratory, Johns Hopkins University, 12-S132, 11100 John Hopkins Road, Laurel, MD 20723-6099 sug: subj: Military Personnel Biochemistry Genomics Population Surveillance Methods Occupational Exposure Specimen Handling Methods Immunity Gene Expression Profiling Specimen Handling Standards Hazardous Materials Scales ab: Systems biology ('omics) technologies are emerging as tools for the comprehensive analysis and monitoring of human health. In order for these tools to be used in military medicine, clinical sampling and biobanking will need to be optimized to be compatible with downstream processing and analysis for each class of molecule measured. This article provides an overview of 'omics technologies, including instrumentation, tools, and methods, and their potential application for warfighter exposure monitoring. We discuss the current state and the potential utility of personalized data from a variety of 'omics sources including genomics, epigenomics, transcriptomics, metabolomics, proteomics, lipidomics, and efforts to combine their use. Issues in the "sample-to-answer" workflow, including collection and biobanking are discussed, as well as national efforts for standardization and clinical interpretation. Establishment of these emerging capabilities, along with accurate xenobiotic monitoring, for the Department of Defense could provide new and effective tools for environmental health monitoring at all duty stations, including deployed locations. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|