Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment.

Background: Fasting serum phosphorus (P) was reported to be inversely related to serum glucose and insulin, while the impact of P ingestion is not well documented. The effect of P intake with or before glucose ingestion on postprandial glucose and insulin statuses was investigated.Method: Two cross...

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Publicado en:Nutrition Journal Vol. 14; pp. 1 - 9
Autores principales: Khattab, May, Abi-Rashed, Christelle, Ghattas, Hala, Hlais, Sani, Obeid, Omar
Formato: research tables/charts Journal Article
Publicado: BioMed Central 10/29/2015
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 10/29/2015
      vid: 14
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      pub: BioMed Central
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        10.1186/s12937-015-0101-5
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        atl: Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment.
      aug:
        au:
          Khattab, May
          Abi-Rashed, Christelle
          Ghattas, Hala
          Hlais, Sani
          Obeid, Omar
        affil: Department of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon
      sug:
        subj:
          Phosphorus Blood
          Phosphorus Administration and Dosage
          Male
          Insulin Blood
          Crossover Design
          Adult
          Postprandial Period
          Glucose Administration and Dosage
          Reference Values
          Young Adult
          Blood Glucose
          Glucose Tolerance Test Statistics and Numerical Data
          Human
          Adult: 19-44 years
          Male
      ab: Background: Fasting serum phosphorus (P) was reported to be inversely related to serum glucose and insulin, while the impact of P ingestion is not well documented. The effect of P intake with or before glucose ingestion on postprandial glucose and insulin statuses was investigated.Method: Two cross over experiments using healthy male subjects were conducted. Experiment 1: Overnight fasted subjects (n = 7) randomly received: 500 mg of P tablets, glucose (75 g) solution with placebo or 500 mg of P tablets. Experiment 2: Overnight fasted subjects (n = 8) underwent similar procedures to those of experiment 1, except that placebo or 500 mg P tablets were given 60 min prior to glucose ingestion.Results: In both experiments, serum P decreased following glucose ingestion. Co-ingestion of P with glucose improved, at time 60 min, postprandial glucose (P < 0.05), insulin (P < 0.05), and insulin sensitivity index (p < 0.006), while P pre-ingestion failed to exert similar effect.Conclusion: This study suggests that postprandial glucose and insulin are affected by exogenous P supply, especially when co-ingested with glucose.
      pubtype: Academic Journal
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      ougenre: Article
    language: English
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