Transannular [6 + 4] and Ambimodal Cycloaddition in the Biosynthesis of Heronamide A.

The transannular [6 + 4] cycloaddition proposed as a step in the biosynthesis of heronamide A has been modeled using density functional theory. The proposed cycloaddition is highly stereoselective, affording a single product. The reaction proceeds through an ambimodal transition state that directly...

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Publicado en:Journal of the American Chemical Society Vol. 137; no. 42; pp. 13518 - 13524
Autores principales: Peiyuan Yu, Patel, Ashay, Houk, K. N.
Formato: Artículo
Publicado: American Chemical Society 10/28/2015
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Acceso en línea:Ver este registro en EBSCOhost