Transannular [6 + 4] and Ambimodal Cycloaddition in the Biosynthesis of Heronamide A.

The transannular [6 + 4] cycloaddition proposed as a step in the biosynthesis of heronamide A has been modeled using density functional theory. The proposed cycloaddition is highly stereoselective, affording a single product. The reaction proceeds through an ambimodal transition state that directly...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 137; no. 42; pp. 13518 - 13524
Main Authors:	Peiyuan Yu, Patel, Ashay, Houk, K. N.
Format:	Article
Published:	American Chemical Society 10/28/2015
Subjects:	Ring formation (Chemistry) Biosynthesis Amides Density functional theory Biochemical substrates Thermodynamics
Online Access:	View this record in EBSCOhost