| Sumario: | Objective: In this study we aimed to evaluate the prooxidant-antioxidant balance (PAB) in the hospitalized patients in comparison with healthy subjects. Setting: This cross sectional study was done from 2010 to 2012 in Mashhad University of Medical Sciences teaching hospitals. Methods: The PAB assay, which is used in this study, measures the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a measure of redox status. One hundred seventy four patients who were admitted to the hospital, and 171 age and sex-matched healthy subjects were recruited to the study as case and control groups respectively. Anthropometric characteristics, biochemical parameters, prooxidant-antioxidant balance and serum high-sensitivity C-reactive protein (hs-CRP) were assessed in both groups. Statistical analysis was then preformed on the data. Results: PAB values were significantly higher in case group as compared with the control group (P < 0.05). No significant correlation was observed in age, body mass index and hip circumference with serum PAB values PAB values in either group. Also serum levels of the albumin, pre-albumin, and hs-CRP showed no significant correlation with PAB values in the patient group (P < 0.05). Conclusion: Being assessed by PAB assay, hospitalized patients demonstrated significant higher prooxidant antioxidant balance, as compared with the healthy subjects.
|
|---|