No effect on QT intervals of mipomersen, a 2′- O-methoxyethyl modified antisense oligonucleotide targeting ApoB-100 mRNA, in a phase I dose escalation placebo-controlled study, and confirmed by a thorough QT (tQT) study, in healthy subjects.

Purpose: The aim of this study to evaluate the effect of mipomersen on QT intervals in a phase I dose escalation, placebo-controlled study, and a thorough QT (tQT) study in healthy subjects. Methods: In the initial phase I study, 29 healthy subjects received either single or multiple (for 4 weeks) a...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 72; no. 3; pp. 267 - 276
Main Authors:	Yu, Rosie, Gunawan, Rudy, Li, Zhaoyang, Mittleman, Robert, Mahmood, Asif, Grundy, John, Singleton, Walter, Geary, Richard, Wang, Yanfeng
Format:	clinical trial equations & formulas research tables/charts Journal Article
Published:	Springer Nature Mar2016
Online Access:	View this record in EBSCOhost