Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease.

Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammato...

Full description

Bibliographic Details
Published in:	Journal of Infectious Diseases Vol. 214; no. 1; pp. 161 - 166
Main Authors:	Farage Frade, Amanda, Laugier, Laurie, Rodrigues Pinto Ferreira, Ludmila, Andrade Baron, Monique, Benvenuti, Luiz Alberto, Camillo Teixeira, Priscila, Cunha Navarro, Isabela, Cabantous, Sandrine, Moraes Ferreira, Frederico, da Silva Cândido, Darlan, Gaiotto, Fabio Antônio, Bacal, Fernando, Pomerantzeff, Pablo, Barros Santos, Ronaldo Honorato, Kalil, Jorge, Cunha-Neto, Edecio, Chevillard, Christophe, Frade, Amanda Farage, Ferreira, Ludmila Rodrigues Pinto, Baron, Monique Andrade
Format:	research tables/charts Journal Article
Published:	Oxford University Press / USA 7/1/2016
Online Access:	View this record in EBSCOhost

Description
Summary:	Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.