Dietary Associations with a Breast Cancer Risk Biomarker Depend on Menopause Status.
We investigated how timing influences the role of diet in breast cancer risk with a cross-sectional study of pre-malignant change in breast tissue. Women with an elevated risk of developing breast cancer (33 premenopausal and 32 postmenopausal) completed the National Cancer Institute's food frequenc...
| Published in: | Nutrition & Cancer Vol. 68; no. 7; pp. 1115 - 1123 |
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| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
Oct2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118031348&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118031348 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Oct2016 vid: 68 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 118031348 118031348 118031348 10.1080/01635581.2016.1208255 118031348 ppf: 1115 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dietary Associations with a Breast Cancer Risk Biomarker Depend on Menopause Status. aug: au: Hidaka, Brandon H. Carlson, Susan E. Kimler, Bruce F. Fabian, Carol J. affil: MD-PhD Program, University of Kansas Medical Center, Kansas City, Kansas, USA sug: subj: Biological Markers Menopause Evaluation Diet Evaluation Breast Neoplasms Diagnosis Nutrition Human Female Breast Neoplasms Physiopathology Cross Sectional Studies Questionnaires Biopsy, Needle Adipose Tissue Breast Anatomy and Histology Fatty Acids Premenopause Evaluation Fatty Acids, Unsaturated Analysis Food Intake Evaluation Data Analysis Software Adult Body Height Body Weight Body Mass Index Evaluation Breast Neoplasms Familial and Genetic Menarche Parity Hormone Replacement Therapy Contraceptives, Oral Funding Source Adult: 19-44 years Female ab: We investigated how timing influences the role of diet in breast cancer risk with a cross-sectional study of pre-malignant change in breast tissue. Women with an elevated risk of developing breast cancer (33 premenopausal and 32 postmenopausal) completed the National Cancer Institute's food frequency questionnaire and underwent random periareolar fine-needle aspiration for evaluation of cytologic atypia, an established risk biomarker. Fatty acid composition of breast adipose was measured in 32 (49%) subjects. We found that premenopausal and postmenopausal women had similar diets, but the associations between atypia and intake of total n-3 polyunsaturated fatty acids (PUFA) and soy differed by menopause status (bothPinteraction< 0.001). Total n-3 PUFA intake was inversely associated with atypia among premenopausal women (P< 0.0001), but not among postmenopausal women (P= 0.91); associations were similar for soy (P= 0.0003 andP= 0.48, respectively). This pattern of dietary interaction with menopause was mirrored in tissue fatty acids (Pinteraction< 0.05), wherein 1) higher levels of linolelaidic acid (an industrially-produced trans fat) and 2) lower levels of docosahexaenoic acid (the predominant long-chain n-3 PUFA) in breast adipose were associated with atypia in premenopausal (bothP< 0.05) but not postmenopausal women (bothP> 0.37). Dietary associations with breast cancer risk are stronger prior to menopause. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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