Brief Report: The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network.

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). The frequency of ASD/NF1 co-occurrence has been subject to debate since the 1980s. This relationship was investigated in a large population-ba...

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Detalles Bibliográficos
Publicado en:	Journal of Autism & Developmental Disorders Vol. 46; no. 10; pp. 3369 - 3377
Autores principales:	Bilder, Deborah, Bakian, Amanda, Stevenson, David, Carbone, Paul, Cunniff, Christopher, Goodman, Alyson, McMahon, William, Fisher, Nicole, Viskochil, David
Formato:	research tables/charts Journal Article
Publicado:	Springer Nature Oct2016
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). The frequency of ASD/NF1 co-occurrence has been subject to debate since the 1980s. This relationship was investigated in a large population-based sample of 8-year-old children identified with ASD (N = 12,271) by the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring (ADDM) Network. Twenty-two (1-in-558) children with ASD had diagnosed NF1, exceeding NF1 general population estimates by four to five fold. Children with ASD/NF1 versus ASD without NF1 were significantly less likely to receive a community-based ASD diagnosis ( p = 0.04) and understand non-verbal communication ( p = 0.001). These findings underscore the importance of including social-communication ability among relevant developmental concerns in children with NF1.