HIV-1 Capsid Function Is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD.

HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its assembly into conical capsids and interactions with host factors. CA is dynamic in the assembled capsid, and residues in functionally important regions of the protein undergo motions spanning many deca...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 138; no. 42; pp. 14066 - 14076
Main Authors:	Huilan Zhang, Guangjin Hou, Manman Lu, Polenova, Tatyana, Jinwoo Ahn, Byeon, In-Ja L., Gronenborn, Angela M., Langmead, Christopher J., Perilla, Juan R., Schulten, Klaus, Ivan Hung, Gor'kov, Peter L., Zhehong Gan, Brey, William W., Case, David A.
Format:	Article
Published:	American Chemical Society 10/26/2016
Subjects:	Capsids HIV Time-dependent density functional theory Nuclear magnetic resonance spectroscopy HIV protease inhibitors Peptides
Online Access:	View this record in EBSCOhost