Higher Fruit Intake Is Related to TNF-α Hypomethylation and Better Glucose Tolerance in Healthy Subjects.
Background/aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes.Methods: Forty normal-weight young women were involved in this cross-sectional study. DNA was isolated fro...
| Publicado en: | Journal of Nutrigenetics & Nutrigenomics Vol. 9; no. 2-4; pp. 95 - 106 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Karger AG
Nov2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119581300&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119581300 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16616499 39R8 jtl: Journal of Nutrigenetics & Nutrigenomics issn: 16616499 maglogo: N pubinfo: dt: Nov2016 vid: 9 iid: 2-4 pid: 2485 pub: Karger AG artinfo: ui: 119581300 119312035 NLM27467584 119312035 10.1159/000448101 NLM27467584 119581300 ppf: 95 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Higher Fruit Intake Is Related to TNF-α Hypomethylation and Better Glucose Tolerance in Healthy Subjects. aug: au: Carraro, Júlia Cristina Cardoso Hermsdorff, Helen Hermana Miranda Mansego, Maria Luisa Zulet, Maria Ángeles Milagro, Fermín I. Bressan, Josefina Martínez, J. alfredo affil: Department of Clinical and Social Nutrition, Universidade Federal de Ouro Preto sug: subj: Blood Glucose Metabolism Fruit DNA Methylation Tumor Necrosis Factor Diet Research Subjects Glucose Tolerance Test Adult Nutrigenomics Cross Sectional Studies Young Adult Female Insulin Blood Adolescence Genes Insulin Resistance Questionnaires Human Adult: 19-44 years Adolescent: 13-18 years Female ab: Background/aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes.Methods: Forty normal-weight young women were involved in this cross-sectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005).Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = -0.460, p = 0.003) and TNF-α total methylation (r = -0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = -0.324, p = 0.041) and TNF-α total methylation (r = -0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = -0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation.Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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