Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine.
Objective: Here, we present the data indicating that chronic treatment with fluoxetine regulates Cav-1/PTEN/PI3K/AKT/GSK-3β signalling pathway and glycogen content in primary cultures of astrocytes with bi-phasic concentration dependence. Results: At lower concentrations, fluoxetine downregulates ge...
| Publicado en: | Psychopharmacology Vol. 234; no. 7; pp. 1069 - 1078 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121841027&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121841027 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Apr2017 vid: 234 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121841027 144005418 10.1007/s00213-017-4547-3 121841027 ppf: 1069 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine. aug: au: Bai, Qiufang Song, Dan Gu, Li Verkhratsky, Alexei Peng, Liang affil: Laboratory of Metabolic Brain Diseases, Institute of Metabolic Disease Research and Drug Development , China Medical University , No. 77, Puhe Road, Shenbei District Shenyang People's Republic of China sug: ab: Objective: Here, we present the data indicating that chronic treatment with fluoxetine regulates Cav-1/PTEN/PI3K/AKT/GSK-3β signalling pathway and glycogen content in primary cultures of astrocytes with bi-phasic concentration dependence. Results: At lower concentrations, fluoxetine downregulates gene expression of Cav-1, decreases membrane content of PTEN, increases activity of PI3K/AKT, and elevates GSK-3β phosphorylation thus suppressing its activity. At higher concentrations, fluoxetine acts in an inverse fashion. As expected, fluoxetine at lower concentrations increased while at higher concentrations decreased glycogen content in astrocytes. Conclusions: Our findings indicate that bi-phasic regulation of glycogen content via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine may be responsible for both therapeutic and side effects of the drug. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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