Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay.
Mutations in the hepatocyte nuclear factor-1α (HNF1a) gene cause maturity-onset diabetes of the young (MODY). Approximately 30% of these mutations generate mRNA transcripts harboring premature termination codons (PTCs). Degradation of such transcripts by the nonsense-mediated decay (NMD) pathway has...
| Publicado en: | Diabetes Vol. 53; no. 2; pp. 500 - 505 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
American Diabetes Association
Feb2004
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| Acceso en línea: | Ver este registro en EBSCOhost |