Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay.

Mutations in the hepatocyte nuclear factor-1α (HNF1a) gene cause maturity-onset diabetes of the young (MODY). Approximately 30% of these mutations generate mRNA transcripts harboring premature termination codons (PTCs). Degradation of such transcripts by the nonsense-mediated decay (NMD) pathway has...

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Bibliographic Details

Published in:	Diabetes Vol. 53; no. 2; pp. 500 - 505
Main Authors:	Harries, Lorna W., Hattersley, Andrew T., Ellard, Sian
Format:	research Journal Article
Published:	American Diabetes Association Feb2004
Online Access:	View this record in EBSCOhost