RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.
Bone undergoes continuous remodeling due to balanced bone formation and resorption mediated by osteoblasts and osteoclasts, respectively. Osteoclasts arise from the macrophage lineage, and their differentiation is dependent on RANKL, a member of the TNF family of cytokines. Here, we have provided ev...
| Publicado en: | Journal of Clinical Investigation Vol. 127; no. 4; pp. 1303 - 1316 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
American Society for Clinical Investigation
4/3/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |