RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.

Bone undergoes continuous remodeling due to balanced bone formation and resorption mediated by osteoblasts and osteoclasts, respectively. Osteoclasts arise from the macrophage lineage, and their differentiation is dependent on RANKL, a member of the TNF family of cytokines. Here, we have provided ev...

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Publicado en:Journal of Clinical Investigation Vol. 127; no. 4; pp. 1303 - 1316
Autores principales: Yoshinori Matsumoto, Larose, Jose, Kent, Oliver A., Lim, Melissa, Changoor, Adele, Zhang, Lucia, Storozhuk, Yaryna, Xiaohong Mao, Grynpas, Marc D., Feng Cong, Rottapel, Robert, Matsumoto, Yoshinori, Mao, Xiaohong, Cong, Feng
Formato: Journal Article
Publicado: American Society for Clinical Investigation 4/3/2017
Acceso en línea:Ver este registro en EBSCOhost