Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development.
The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a co...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 47; no. 11; pp. 3634 - 3646 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125560191&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125560191 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Nov2017 vid: 47 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125560191 125560191 144168355 125560191 10.1007/s10803-017-3280-4 125560191 ppf: 3634 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development. aug: au: Wiggins, Lisa Tian, Lin Levy, Susan Rice, Catherine Lee, Li-Ching Schieve, Laura Pandey, Juhi Daniels, Julie Blaskey, Lisa Hepburn, Susan Landa, Rebecca Edmondson-Pretzel, Rebecca Thompson, William affil: National Center on Birth Defects and Developmental Disabilities (NCBDDD) , Centers for Disease Control and Prevention , 4770 Buford Highway MS E-86 Atlanta USA sug: subj: Autism Spectrum Disorder In Infancy and Childhood Child Development Phenotype Human Algorithms Child Health Screening Diagnosis Child: 6-12 years ab: The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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