Radical Multicomponent Carboamination of [1.1.1]Propellane.

Three-dimensional, small-ring scaffolds are very important in modern drug discovery to expand the available drug-like chemical space and to optimize drug candidates. Among them, bicyclo[1.1.1]pentane (BCP) is regarded as a high-value bioisostere for a phenyl ring or tert-butyl group; it provides an...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 139; no. 49; pp. 17791 - 17795
Main Authors:	Junichiro Kanazawa, Katsuya Maeda, Masanobu Uchiyama
Format:	Article
Published:	American Chemical Society 12/13/2017
Subjects:	Propellanes Amination Pentane Amines Density functional theory Drug development
Online Access:	View this record in EBSCOhost