Radical Multicomponent Carboamination of [1.1.1]Propellane.

Three-dimensional, small-ring scaffolds are very important in modern drug discovery to expand the available drug-like chemical space and to optimize drug candidates. Among them, bicyclo[1.1.1]pentane (BCP) is regarded as a high-value bioisostere for a phenyl ring or tert-butyl group; it provides an...

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Publicado en:	Journal of the American Chemical Society Vol. 139; no. 49; pp. 17791 - 17795
Autores principales:	Junichiro Kanazawa, Katsuya Maeda, Masanobu Uchiyama
Formato:	Artículo
Publicado:	American Chemical Society 12/13/2017
Materias:	Propellanes Amination Pentane Amines Density functional theory Drug development
Acceso en línea:	Ver este registro en EBSCOhost