Highly variable absorption of clavulanic acid during the day: a population pharmacokinetic analysis.

Objectives: To calculate the clavulanic acid exposure of oral amoxicillin/clavulanic acid dosing regimens, to investigate variability using a population pharmacokinetic model and to explore target attainment using Monte Carlo simulations.Methods: Two groups of healthy male volunteers received amoxic...

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Publicado en:	Journal of Antimicrobial Chemotherapy (JAC) Vol. 73; no. 2; pp. 469 - 477
Autores principales:	Mouton, Johan W., De Velde, Femke, De Winter, Brenda C. M., Van Gelder, Teun, Koch, Birgit C. P.
Formato:	research Journal Article
Publicado:	Oxford University Press / USA Feb2018
Acceso en línea:	Ver este registro en EBSCOhost