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Tomentodione E, a new sec-pentyl syncarpic acid-based meroterpenoid from the leaves of Rhodomyrtus tomentosa.

A new meroterpenoid, tomentodione E (1), along with four known ones (2-5) were isolated from the leaves of Rhodomyrtus tomentosa. Their structures were elucidated based on extensive spectroscopic data as well as computational methods. Compound 1 represents the first example of meroterpenoid possessi...

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Publicado en:Journal of Asian Natural Products Research Vol. 20; no. 1; pp. 67 - 75
Autores principales: Liu, Jie, Song, Jian-Guo, Su, Jun-Cheng, Huang, Xiao-Jun, Ye, Wen-Cai, Wang, Ying
Formato: pictorial research tables/charts Journal Article
Publicado: Taylor & Francis Ltd Jan2018
Acceso en línea:Ver este registro en EBSCOhost
Sumario:A new meroterpenoid, tomentodione E (1), along with four known ones (2-5) were isolated from the leaves of Rhodomyrtus tomentosa. Their structures were elucidated based on extensive spectroscopic data as well as computational methods. Compound 1 represents the first example of meroterpenoid possessing a sec-pentyl syncarpic acid motif coupled with a caryophyllene. Compounds 1-4 were evaluated for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay, and 2 showed potent in vitro anti-RSV effect.