Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects.

Purpose: The aim of this analysis is to compare the pharmacokinetics of drug substrates in healthy Chinese and European subjects of aligned CYP2C9, CYP2C19, or CYP2D6 enzyme activity, providing further insight into drivers of interethnic differences in pharmacokinetics.Methods: Following identificat...

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Publicado en:European Journal of Clinical Pharmacology Vol. 74; no. 3; pp. 285 - 297
Autores principales: Lu, Sijie, Nand, R. A., Yang, J. S., Chen, Gang, Gross, A. S.
Formato: research systematic review tables/charts Journal Article
Publicado: Springer Nature Mar2018
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Mar2018
      vid: 74
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      pub: Springer Nature
      place: New York, New York
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        127943479
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        127943479
        10.1007/s00228-017-2375-3
        127943479
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      tig:
        atl: Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects.
      aug:
        au:
          Lu, Sijie
          Nand, R. A.
          Yang, J. S.
          Chen, Gang
          Gross, A. S.
        affil: School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China
      sug:
        subj:
          Cytochrome P-450 Enzyme System Pharmacokinetics
          Chinese Persons
          Ethnic Groups Europe
          Cultural Diversity
          Human
          Systematic Review
          Polymorphism, Genetic
          Europe
      ab: Purpose: The aim of this analysis is to compare the pharmacokinetics of drug substrates in healthy Chinese and European subjects of aligned CYP2C9, CYP2C19, or CYP2D6 enzyme activity, providing further insight into drivers of interethnic differences in pharmacokinetics.Methods: Following identification of appropriate drug substrates, a comprehensive and structured literature search was conducted to identify single-dose pharmacokinetic data in healthy Chinese or European subjects with reported CYP2C9, CYP2C19, or CYP2D6 activity (genotype or phenotype). The ratio of drug AUC in the Chinese and European subjects classified with aligned enzyme activity was calculated (ethnicity ratio (ER)).Results: For 22/25 drugs identified, the ERs calculated indicated no or only limited interethnic differences in exposure (<twofold) in Chinese and European subjects with aligned polymorphic enzyme activity. The interethnic differences observed can reflect differences across populations in additional determinants of pharmacokinetics, although the notable between study variation and change over time in methods used to assign enzyme activity may also be contributing factors. There was no association between drug substrate fraction metabolized (fm) for CYP2C9, CYP2C19, or CYP2D6 and the ERs calculated.Conclusion: The spectrum of pharmacokinetic determinants for each drug substrate and their differences across ethnic groups must be considered on a case-by-case basis in addition to metabolism by CYP2C9, CYP2C19, or CYP2D6. This analysis has also highlighted the challenges which arise when comparing published datasets if consistent methods to assign polymorphic enzyme activity have not been used.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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