The amount and types of fatty acids acutely affect insulin, glycemic and gastrointestinal peptide responses but not satiety in metabolic syndrome subjects.
Purpose: Limited clinical evidence is available on the effects of amount and types of dietary fats on postprandial insulinemic and gastrointestinal peptide responses in metabolic syndrome subjects. We hypothesized that meals enriched with designated: (1) amount of fats (50 vs 20 g), (2) fats with di...
| Publicado en: | European Journal of Nutrition Vol. 57; no. 1; pp. 179 - 191 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128149295&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128149295 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2018 vid: 57 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128149295 128149295 128149295 10.1007/s00394-016-1307-9 128149295 ppf: 179 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The amount and types of fatty acids acutely affect insulin, glycemic and gastrointestinal peptide responses but not satiety in metabolic syndrome subjects. aug: au: Chang, Chee-Yan Kanthimathi, M. S. Tan, Alexander Tong-Boon Nesaretnam, Kalanithi Teng, Kim-Tiu affil: , Department of Molecular Medicine, Faculty of Medicine, University of Malaya Centre for Proteomics Research (UMCPR), University of Malaya, 50603, Kuala Lumpur, Malaysia sug: subj: Fatty Acids Insulin Blood Satiation Metabolic Syndrome X Glycemic Index Dietary Fats Gastrointestinal Hormones Peptides Human Randomized Controlled Trials Meals Fatty Acids, Saturated Fatty Acids, Monounsaturated Fatty Acids, Unsaturated Crossover Design Double-Blind Studies Male Female Dietary Sucrose C-Peptide Glucose Time Factors Comparative Studies Ghrelin Cholecystokinin Male Female ab: Purpose: Limited clinical evidence is available on the effects of amount and types of dietary fats on postprandial insulinemic and gastrointestinal peptide responses in metabolic syndrome subjects. We hypothesized that meals enriched with designated: (1) amount of fats (50 vs 20 g), (2) fats with differing fatty acid composition (saturated, SFA; monounsaturated, MUFA or n-6 polyunsaturated fatty acids, PUFA) would affect insulinemic and gastrointestinal peptide releases in metabolic syndrome subjects.Methods: Using a randomized, crossover and double-blinded design, 15 men and 15 women with metabolic syndrome consumed high-fat meals enriched with SFA, MUFA or n-6 PUFA, or a low-fat/high-sucrose (SUCR) meal. C-peptide, insulin, glucose, gastrointestinal peptides and satiety were measured up to 6 h.Results: As expected, SUCR meal induced higher C-peptide (45 %), insulin (45 %) and glucose (49 %) responses compared with high-fat meals regardless of types of fatty acids (<italic>P</italic> < 0.001). Interestingly, incremental area under the curve (AUC0-120min) for glucagon-like peptide-1 was higher after SUCR meal compared with MUFA (27 %) and n-6 PUFA meals (23 %) (<italic>P</italic> = 0.01). AUC0-120min for glucose-dependent insulinotropic polypeptide was higher after SFA meal compared with MUFA (23 %) and n-6 PUFA meals (20 %) (<italic>P</italic> = 0.004). Significant meal x time interaction (<italic>P</italic> = 0.007) was observed for ghrelin, but not cholecystokinin and satiety.Conclusions: The amount of fat regardless of the types of fatty acids affects insulin and glycemic responses. Both the amount and types of fatty acids acutely affect the gastrointestinal peptide release in metabolic syndrome subjects, but not satiety. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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