Rice bran protein hydrolysates reduce arterial stiffening, vascular remodeling and oxidative stress in rats fed a high-carbohydrate and high-fat diet.
Purpose: Rice bran protein hydrolysates (RBPH) contain highly nutritional proteins and antioxidant compounds which show benefits against metabolic syndrome (MetS). Increased arterial stiffness and the components of MetS have been shown to be associated with an increased risk of cardiovascular diseas...
| Publicado en: | European Journal of Nutrition Vol. 57; no. 1; pp. 219 - 231 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128149299&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128149299 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2018 vid: 57 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128149299 128149299 128149299 10.1007/s00394-016-1311-0 128149299 ppf: 219 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Rice bran protein hydrolysates reduce arterial stiffening, vascular remodeling and oxidative stress in rats fed a high-carbohydrate and high-fat diet. aug: au: Senaphan, Ketmanee Sangartit, Weerapon Pakdeechote, Poungrat Kukongviriyapan, Veerapol Pannangpetch, Patchareewan Thawornchinsombut, Supawan Greenwald, Stephen E. Kukongviriyapan, Upa affil: , Department of Physiology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand sug: subj: Rice Administration and Dosage Proteins Administration and Dosage Arterial Stiffness Vascular Remodeling Oxidative Stress Carbohydrates Dietary Fats Food Intake Animal Studies Rats Metabolic Syndrome X Fructose Hyperglycemia Insulin Resistance Hyperlipidemia Hypertension Pulse Wave Velocity Hypertrophy Gene Expression Dietary Supplementation Angiotensin-Converting Enzyme Blood Tumor Necrosis Factor Blood Malondialdehyde Blood Superoxide Dismutase Blood Oxidoreductases Blood Nitrates Blood Nitric Oxide Synthases Blood Rice Pharmacodynamics Proteins Pharmacodynamics ab: Purpose: Rice bran protein hydrolysates (RBPH) contain highly nutritional proteins and antioxidant compounds which show benefits against metabolic syndrome (MetS). Increased arterial stiffness and the components of MetS have been shown to be associated with an increased risk of cardiovascular disease. This study aimed to investigate whether RBPH could alleviate the metabolic disorders, arterial stiffening, vascular remodeling, and oxidative stress in rats fed a high-carbohydrate and high-fat (HCHF) diet.Methods: Male Sprague–Dawley rats were fed either a standard chow and tap water or a HCHF diet and 15 % fructose solution for 16 weeks. HCHF rats were treated orally with RBPH (250 or 500 mg/kg/day) for the final 6 weeks of the experimental period.Results: Rats fed with HCHF diet had hyperglycemia, insulin resistance, dyslipidemia, hypertension, increased aortic pulse wave velocity, aortic wall hypertrophy and vascular remodeling with increased MMP-2 and MMP-9 expression. RBPH supplementation significantly alleviated these alterations (<italic>P</italic> < 0.05). Moreover, RBPH reduced the levels of angiotensin-converting enzyme (ACE) and tumor necrosis factor-alpha in plasma. Oxidative stress was also alleviated after RBPH treatment by decreasing plasma malondialdehyde, reducing superoxide production and suppressing p47phox NADPH oxidase expression in the vascular tissues of HCHF rats. RBPH increased plasma nitrate/nitrite level and up-regulated eNOS expression in the aortas of HCHF-diet-fed rats, indicating that RBPH increased NO production.Conclusion: RBPH mitigate the deleterious effects of HCHF through potential mechanisms involving enhanced NO bioavailability, anti-ACE, anti-inflammatory and antioxidant properties. RBPH could be used as dietary supplements to minimize oxidative stress and vascular alterations triggered by MetS. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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