Designing a Chimeric Vaccine Against Colorectal Cancer.
Background: Colorectal cancer is the major cause of death worldwide. Recently, cancer immunotherapy has been used in cancer prevention and treatment which has led to immune system response to cancerous cells and their elimination. Recent studies were conducted to specifically target tumor marker to...
| Publicado en: | International Journal of Cancer Management Vol. 10; no. 12; pp. 1 - 14 |
|---|---|
| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Medical Journals Commission of the Ministry of Health & Medical Education
Dec2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128200642&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128200642 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25384422 L6AI jtl: International Journal of Cancer Management issn: 25384422 maglogo: N pubinfo: dt: Dec2017 vid: 10 iid: 12 pid: 66482 pub: Medical Journals Commission of the Ministry of Health & Medical Education artinfo: ui: 128200642 128200642 128200642 10.5812/ijcm.7743 128200642 ppf: 1 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Designing a Chimeric Vaccine Against Colorectal Cancer. aug: au: Malekshahi, Ziba Veisi Rajabibazl, Masoumeh Ebrahimizadeh, Walead Amani, Jafar Negahdari, Babak affil: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IR Iran sug: subj: Colorectal Neoplasms Drug Therapy Colorectal Neoplasms Immunology Vaccines Drug Design Antigens, Tumor Tumor Markers, Biological Human Bioinformatics Biochemical Phenomena Genes Carrier Proteins Proteins Computer Simulation ab: Background: Colorectal cancer is the major cause of death worldwide. Recently, cancer immunotherapy has been used in cancer prevention and treatment which has led to immune system response to cancerous cells and their elimination. Recent studies were conducted to specifically target tumor marker to design vaccine. Objectives: Here, we designed a vaccine chimeric including CEA and CA19-9 against colorectal cancer. Methods: The construct was analyzed, using bioinformatics tools and servers. The physicochemical properties, structures, antigenicity, stability, MHC binding properties, and ligand-receptor docking of chimeric protein (CE-CA) were predicted. Results: The results showed the structure of CE-CA has suitable form and separates each domain; furthermore, the epitope mapping did not change after combination. Conclusions: The results showed that the construct can be appropriate vaccine against colorectal cancer and could generate potent immune response against this cancer. In silico tools are useful to design vaccine. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|