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Designing a Chimeric Vaccine Against Colorectal Cancer.

Background: Colorectal cancer is the major cause of death worldwide. Recently, cancer immunotherapy has been used in cancer prevention and treatment which has led to immune system response to cancerous cells and their elimination. Recent studies were conducted to specifically target tumor marker to...

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Published in:International Journal of Cancer Management Vol. 10; no. 12; pp. 1 - 14
Main Authors: Malekshahi, Ziba Veisi, Rajabibazl, Masoumeh, Ebrahimizadeh, Walead, Amani, Jafar, Negahdari, Babak
Format: pictorial research tables/charts Journal Article
Published: Medical Journals Commission of the Ministry of Health & Medical Education Dec2017
Online Access:View this record in EBSCOhost
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      jtl: International Journal of Cancer Management
      issn: 25384422
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      dt: Dec2017
      vid: 10
      iid: 12
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      pub: Medical Journals Commission of the Ministry of Health & Medical Education
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        10.5812/ijcm.7743
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      tig:
        atl: Designing a Chimeric Vaccine Against Colorectal Cancer.
      aug:
        au:
          Malekshahi, Ziba Veisi
          Rajabibazl, Masoumeh
          Ebrahimizadeh, Walead
          Amani, Jafar
          Negahdari, Babak
        affil: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
      sug:
        subj:
          Colorectal Neoplasms Drug Therapy
          Colorectal Neoplasms Immunology
          Vaccines
          Drug Design
          Antigens, Tumor
          Tumor Markers, Biological
          Human
          Bioinformatics
          Biochemical Phenomena
          Genes
          Carrier Proteins
          Proteins
          Computer Simulation
      ab: Background: Colorectal cancer is the major cause of death worldwide. Recently, cancer immunotherapy has been used in cancer prevention and treatment which has led to immune system response to cancerous cells and their elimination. Recent studies were conducted to specifically target tumor marker to design vaccine. Objectives: Here, we designed a vaccine chimeric including CEA and CA19-9 against colorectal cancer. Methods: The construct was analyzed, using bioinformatics tools and servers. The physicochemical properties, structures, antigenicity, stability, MHC binding properties, and ligand-receptor docking of chimeric protein (CE-CA) were predicted. Results: The results showed the structure of CE-CA has suitable form and separates each domain; furthermore, the epitope mapping did not change after combination. Conclusions: The results showed that the construct can be appropriate vaccine against colorectal cancer and could generate potent immune response against this cancer. In silico tools are useful to design vaccine.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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