CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects.

Purpose: The pharmacokinetics (PK) of labetalol show wide inter-subject variability, but the genetic causes for this are largely undetermined. This study was performed to examine whether common polymorphisms in UGT1A1, UGT2B7, CYP2C19 and ABCB1 affect the PK of labetalol. Methods: The PK of labetalo...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 69; no. 4; pp. 799 - 807
Main Authors:	Chan, Sze, Hu, Miao, Ko, Sara, Tam, Catherine, Fok, Benny, Yin, Ophelia, Chow, Moses, Tomlinson, Brian
Format:	research tables/charts Journal Article
Published:	Springer Nature Apr2013
Online Access:	View this record in EBSCOhost