Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects.
Purpose: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorpti...
| Publicado en: | European Journal of Nutrition Vol. 57; no. 3; pp. 929 - 939 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128597979&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128597979 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2018 vid: 57 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128597979 128597979 128597979 10.1007/s00394-016-1376-9 128597979 ppf: 929 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects. aug: au: Purpura, Martin Lowery, Ryan P. Wilson, Jacob M. Mannan, Haider Münch, Gerald Razmovski-Naumovski, Valentina affil: Increnovo LLC, 2138 E Lafayette Pl, 53202, Milwaukee, WI, USA sug: subj: Curcumin Physiology Curcumin Pharmacokinetics Biological Availability Human Double-Blind Studies Crossover Design Blood Chemical Analysis Pretest-Posttest Design Statistical Significance Administration, Oral Randomized Controlled Trials Random Assignment ab: Purpose: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO).Methods: Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period.Results: CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC0−12) in comparison with the unformulated StdC.Conclusion: The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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