Arylketone π-Conjugation Controls Enantioselectivity in Asymmetric Alkynylations Catalyzed by Centrochiral Ruthenium Complexes.

The origin of enantioselectivity in the asymmetric alkynylation of trihalomethyl ketones catalyzed by octahedral stereogenic-at-ruthenium complexes has been investigated through density functional theory calculations. Computational results support a mechanism involving formation of a ruthenium acety...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 140; no. 15; pp. 5146 - 5153
Main Authors:	Shuming Chen, Yu Zheng, Tianjiao Cui, Meggers, Eric, Houk, K. N.
Format:	Article
Published:	American Chemical Society 4/18/2018
Subjects:	Bioconjugates Enantioselective catalysis Ruthenium compounds Ketones Density functional theory
Online Access:	View this record in EBSCOhost