The Role of the Active Site Flap in Streptavidin/Biotin Complex Formation.

Obtaining a detailed description of how active site flap motion affects substrate or ligand binding will advance structure-based drug design (SBDD) efforts on systems including the kinases, HSP90, HIV protease, ureases, etc. Through this understanding, we will be able to design better inhibitors and...

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Publicado en:	Journal of the American Chemical Society Vol. 140; no. 16; pp. 5434 - 5447
Autores principales:	Bansal, Nupur, Zheng Zheng, Lin Frank Song, Jun Pei, Merz, Jr., Kenneth M.
Formato:	Artículo
Publicado:	American Chemical Society 4/25/2018
Materias:	Streptavidin Biotin Ligand binding (Biochemistry) Proteins Free energy (Thermodynamics) Kinases Urease
Acceso en línea:	Ver este registro en EBSCOhost