The Role of the Active Site Flap in Streptavidin/Biotin Complex Formation.

Obtaining a detailed description of how active site flap motion affects substrate or ligand binding will advance structure-based drug design (SBDD) efforts on systems including the kinases, HSP90, HIV protease, ureases, etc. Through this understanding, we will be able to design better inhibitors and...

Full description

Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 140; no. 16; pp. 5434 - 5447
Main Authors:	Bansal, Nupur, Zheng Zheng, Lin Frank Song, Jun Pei, Merz, Jr., Kenneth M.
Format:	Article
Published:	American Chemical Society 4/25/2018
Subjects:	Streptavidin Biotin Ligand binding (Biochemistry) Proteins Free energy (Thermodynamics) Kinases Urease
Online Access:	View this record in EBSCOhost