LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance.

Cofilin phospho-regulation is important for actin filament turnover and is implicated in cancer. Phosphorylation of cofilin is mediated by LIM kinases (LIMKs) and dephosphorylation by Slingshot phosphatases (SSH). LIMKs and SSH promote cancer cell invasion and metastasis and represent novel anti-can...

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Bibliographic Details

Published in:	Virchows Archiv: European Journal of Pathology Vol. 472; no. 5; pp. 727 - 738
Main Authors:	Aggelou, Helen, Chadla, Panagiota, Nikou, Sofia, Karteri, Sofia, Maroulis, Ioannis, Kalofonos, Haralabos P., Papadaki, Helen, Bravou, Vasiliki
Format:	Journal Article
Published:	Springer Nature May2018
Online Access:	View this record in EBSCOhost