Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury.

Purpose and Method: This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). Results: Compared to uninjured peers, children with TBI demonstrated l...

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Detalles Bibliográficos
Publicado en:	Developmental Neurorehabilitation Vol. 21; no. 7; pp. 423 - 431
Autores principales:	Stephens, Jaclyn A., Salorio, Cynthia F., Barber, Anita D., Risen, Sarah R., Mostofsky, Stewart H., Suskauer, Stacy J.
Formato:	diagnostic images research tables/charts Journal Article
Publicado:	Taylor & Francis Ltd Oct2018
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	Purpose and Method: This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). Results: Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks. Conclusion: Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 may relate to longterm functional outcomes in chronic pediatric TBI.