Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.
Purpose: Previous studies demonstrated the utility of [18F]fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in healthy control (HC) and type 1 diabetes mellit...
| Publicado en: | Molecular Imaging & Biology Vol. 20; no. 5; pp. 835 - 846 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131752871&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131752871 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Oct2018 vid: 20 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131752871 131752871 NLM29468404 131752871 10.1007/s11307-018-1170-6 NLM29468404 131752871 ppf: 835 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes. aug: au: Naganawa, Mika Lim, Keunpoong Nabulsi, Nabeel B. Lin, Shu-fei Labaree, David Ropchan, Jim Herold, Kevan C. Huang, Yiyun Harris, Paul Ichise, Masanori Cline, Gary W. Carson, Richard E. affil: Yale University, P.O. Box 208048, 06520-8048, New Haven, CT, USA sug: subj: Heterocyclic Compounds Analogs and Derivatives Diabetes Mellitus, Type 1 Metabolism Diabetes Mellitus, Type 1 Fluorine Radioisotopes Blood Young Adult Heterocyclic Compounds Pharmacokinetics Fluorine Radioisotopes Diabetes Mellitus, Type 1 Blood Case Control Studies Adult Heterocyclic Compounds Blood Human Male Chemistry Female Heterocyclic Compounds Fluorine Radioisotopes Pharmacokinetics Injections Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Male Female ab: Purpose: Previous studies demonstrated the utility of [18F]fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in healthy control (HC) and type 1 diabetes mellitus (T1DM) groups. Quantification of specific binding requires measurement of non-displaceable uptake. Our goal was to identify a reference tissue (renal cortex or spleen) to quantify pancreatic non-specific binding of [18F]FP-(+)-DTBZ with the inactive enantiomer, [18F]FP-(-)-DTBZ. This was the first human study of [18F]FP-(-)-DTBZ.Procedures: Six HCs and four T1DM patients were scanned on separate days after injection of [18F]FP-(+)-DTBZ or [18F]FP-(-)-DTBZ. Distribution volumes (VT) and standardized uptake values (SUVs) were compared between groups. Three methods for calculation of non-displaceable uptake (VND) or reference SUV were applied: (1) use of [18F]FP-(+)-DTBZ reference VT as VND, assuming VND is uniform across organs; (2) use of [18F]FP-(-)-DTBZ pancreatic VT as VND, assuming that VND is uniform between enantiomers in the pancreas; and (3) use of a scaled [18F]FP-(+)-DTBZ reference VT as VND, assuming that a ratio of non-displaceable uptake between organs is uniform between enantiomers. Group differences in VT (or SUV), binding potential (BPND), or SUV ratio (SUVR) were estimated using these three methods.Results: [18F]FP-(-)-DTBZ VT values were different among organs, and VT(+) and VT(-) were also different in the renal cortex and spleen. Method 3 with the spleen to estimate VND (or reference SUV) gave the highest non-displaceable uptake and the largest HC vs. T1DM group differences. Significant group differences were also observed in VT (or SUV) with method 1 using spleen. SUV was affected by differences in the input function between groups and between enantiomers.Conclusions: Non-displaceable uptake was different among organs and between enantiomers. Use of scaled spleen VT values for VND is a suitable method for quantification of VMAT2 in the pancreas. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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