| Sumario: | Background: Whether the underlying disease affects the outcomes in pyoderma gangrenosum (PG) is unclear.Objectives: To determine the impact of comorbid disease associations and concomitant procedural treatments on patient outcomes in hospitalizations of patients with PG.Methods: A cross-sectional analysis of the National Inpatient Sample for hospitalizations of patients with PG from the years 2002 to 2011, analyzing in-hospital mortality rate and health care resource utilization.Results: Inflammatory bowel disease was the most frequent comorbid association, followed by inflammatory arthritis, hematologic malignancies/dyscrasia, and vasculitis. Multivariable modeling showed that vasculitis and hematologic malignancy/dyscrasia, when compared with inflammatory bowel disease, were associated with a 4-fold to 6-fold increased risk of in-hospital mortality and increasing health care resource utilization. Inpatient procedural interventions, including skin grafts, biopsies, and debridement, did not affect mortality and were associated with an increased length of stay.Limitations: The database does not account for outpatient follow-up; additionally, there was a low rate of coded comorbid conditions.Conclusions: Comprehensive evaluation to determine the underlying comorbidity for patients with PG is important for patient risk stratification.
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