5-HT1A parital agonism and 5-HT7 antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA.

Rationale: The effect of atypical antipsychotic drugs (AAPDs), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (CIAS), has been suggested to be due, in part, to enhancing release of dopamine (DA), acetylcholine (ACh), and glutamate (Glu) in cortex and hippocampus.Resu...

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Bibliographic Details
Published in:Psychopharmacology Vol. 235; no. 10; pp. 2795 - 2809
Main Authors: Huang, Mei, Kwon, Sunoh, Rajagopal, Lakshmi, He, Wenqi, Meltzer, Herbert Y.
Format: Journal Article
Published: Springer Nature Oct2018
Online Access:View this record in EBSCOhost