| Summary: | Aims The current study examines the relationship between alcohol dependence severity and delay discounting neural activation. Methods Participants (N = 17; 6 female) completed measures of alcohol use and severity and a functional magnetic resonance imaging version of a delay discounting task. Results Alcohol dependence severity was negatively associated with activation in superior frontal gyrus during impulsive relative to delayed decisions, and positively associated with activation in paracingulate gyrus and frontal pole in delayed relative to impulsive decisions. Conclusions These results indicate that alcohol dependence severity tracks closely with dysregulations in cognitive control and reward evaluation areas during impulsive and delayed decisions, respectively. Delay discounting may be a useful construct in capturing these cognitive dysregulations as alcohol use disorders become more severe. Short summary Among alcohol-dependent individuals, alcohol dependence severity is associated with overactivation of ventromedial prefrontal areas during delayed and underactivation of dorsolateral prefrontal regions during impulsive reward decisions.
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