Effects of Alcohol Dependence Severity on Neural Correlates of Delay Discounting.
Aims The current study examines the relationship between alcohol dependence severity and delay discounting neural activation. Methods Participants (N = 17; 6 female) completed measures of alcohol use and severity and a functional magnetic resonance imaging version of a delay discounting task. Result...
| Publicado en: | Alcohol & Alcoholism. Supplement Vol. 52; no. 4; pp. 506 - 516 |
|---|---|
| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jul2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132131943&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132131943 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13586173 AWR7 jtl: Alcohol & Alcoholism. Supplement issn: 13586173 maglogo: N pubinfo: dt: Jul2017 vid: 52 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 132131943 132131943 132131943 10.1093/alcalc/agx015 132131943 ppf: 506 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of Alcohol Dependence Severity on Neural Correlates of Delay Discounting. aug: au: Lim, Aaron C. Cservenka, Anita Ray, Lara A. affil: Department of Psychology , University of California , Los Angeles , CA , USA sug: subj: Alcoholism Diagnosis Severity of Illness Delay Discounting Human Female Alcohol Abuse Diagnosis Magnetic Resonance Imaging Methods Task Performance and Analysis Frontal Lobe Temporal Lobe Cognition Reward Substance Use Disorders Female ab: Aims The current study examines the relationship between alcohol dependence severity and delay discounting neural activation. Methods Participants (N = 17; 6 female) completed measures of alcohol use and severity and a functional magnetic resonance imaging version of a delay discounting task. Results Alcohol dependence severity was negatively associated with activation in superior frontal gyrus during impulsive relative to delayed decisions, and positively associated with activation in paracingulate gyrus and frontal pole in delayed relative to impulsive decisions. Conclusions These results indicate that alcohol dependence severity tracks closely with dysregulations in cognitive control and reward evaluation areas during impulsive and delayed decisions, respectively. Delay discounting may be a useful construct in capturing these cognitive dysregulations as alcohol use disorders become more severe. Short summary Among alcohol-dependent individuals, alcohol dependence severity is associated with overactivation of ventromedial prefrontal areas during delayed and underactivation of dorsolateral prefrontal regions during impulsive reward decisions. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|