Detecting Rare Mutations with Heterogeneous Effects Using a Family-Based Genetic Random Field Method.
The genetic etiology of many complex diseases is highly heterogeneous. A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci. Although these disease-susceptibility mutations can be collectively common in the population, they...
| Published in: | Genetics Vol. 210; no. 2; pp. 463 - 477 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Published: |
Oxford University Press / USA
Oct2018
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| Online Access: | View this record in EBSCOhost |