CRISPR-Cas9 Mediated RNase L Knockout Regulates Cellular Function of PK-15 Cells and Increases PRV Replication.

Ribonuclease L (RNase L) is an important antiviral endoribonuclease regulated by type I IFN. RNase L is activated by viral infection and dsRNA. Because the role of swine RNase L (sRNase L) is not fully understood, in this study, we generated a sRNase L knockout PK-15 (KO-PK) cell line through the CR...

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Bibliographic Details

Published in:	BioMed Research International pp. 1 - 11
Main Authors:	Sui, Chao, Jiang, Dandan, Wu, Xiangju, Cong, Xiaoyan, Li, Feng, Shang, Yingli, Wang, Jinqiu, Liu, Sidang, Shan, Hu, Qi, Jing, Du, Yijun
Format:	pictorial research tables/charts Journal Article
Published:	Wiley-Blackwell 3/3/2019
Online Access:	View this record in EBSCOhost