Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.

Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high...

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Detalles Bibliográficos
Publicado en:Journal of Autism & Developmental Disorders Vol. 49; no. 4; pp. 1402 - 1410
Autores principales: Boisgontier, Jennifer, Laidi, Charles, Hotier, Sevan, d'Albis, Marc-Antoine, Houenou, Josselin, Gaman, Alexandru, Scheid, Isabelle, Leboyer, Marion, Toledano, Elie, Ly-Le Moal, Myriam, Delorme, Richard, de Pierrefeu, Amicie, Duchesnay, Edouard, Petit, Julie, Bolognani, Federico, Czech, Christian, Bouquet, Céline, Holiga, Štefan, Dukart, Juergen, Amestoy, Anouck
Formato: research tables/charts Journal Article
Publicado: Springer Nature Apr2019
Acceso en línea:Ver este registro en EBSCOhost
Descripción
Sumario:Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population.