Diagnostic accuracy of hepatic proton density fat fraction measured by magnetic resonance imaging for the evaluation of liver steatosis with histology as reference standard: a meta-analysis.
Objectives: The aim of this meta-analysis was to evaluate the diagnostic accuracy of hepatic magnetic resonance imaging-proton density fat fraction (MRI-PDFF) for the assessment of liver steatosis (LS) with histology as reference standard.Methods: A systematic literature search was performed to iden...
| Published in: | European Radiology Vol. 29; no. 10; pp. 5180 - 5190 |
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| Main Authors: | , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Oct2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138395926&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138395926 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2019 vid: 29 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138395926 138395926 144170081 NLM30877459 138395926 10.1007/s00330-019-06071-5 NLM30877459 138395926 ppf: 5180 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diagnostic accuracy of hepatic proton density fat fraction measured by magnetic resonance imaging for the evaluation of liver steatosis with histology as reference standard: a meta-analysis. aug: au: Qu, Yali Li, Mou Hamilton, Gavin Zhang, Yingzhen N. Song, Bin affil: Department of Radiology, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, 610041, Chengdu, Sichuan, China sug: subj: Biopsy Methods Nonalcoholic Fatty Liver Disease Diagnosis Magnetic Resonance Imaging Methods Liver Pathology Human ROC Curve Reproducibility of Results Meta Analysis Ferrans and Powers Quality of Life Index Scales Funding Source ab: Objectives: The aim of this meta-analysis was to evaluate the diagnostic accuracy of hepatic magnetic resonance imaging-proton density fat fraction (MRI-PDFF) for the assessment of liver steatosis (LS) with histology as reference standard.Methods: A systematic literature search was performed to identify pertinent studies. Quality analyses were conducted by Quality Assessment of Diagnostic Accuracy Studies-2. Diagnostic data were extracted and inconsistency index was calculated for LS≥G1, LS≥G2, and LS=G3, respectively. The area under summary receiver operating characteristic curve (AUC) served as the indicator of diagnostic accuracy. The pooled sensitivity and specificity were calculated if threshold effect was absent.Results: Thirteen studies containing 1100 subjects were included. There was significant threshold effect for LS≥G1. The AUCs for LS≥G1, LS≥G2, and LS=G3 were 0.98 (95% confidence interval (CI) 0.76, 1.00), 0.91 (95% CI 0.89, 0.94), and 0.92 (95% CI 0.89, 0.94), respectively. The pooled sensitivities for LS≥G2 and LS=G3 were 0.83 (95% CI 0.75, 0.88) and 0.79 (95% CI 0.63, 0.90), respectively; the pooled specificities for LS≥G2 and LS=G3 were 0.89 (95% CI 0.84, 0.92) and 0.89 (95% CI 0.84, 0.92), respectively.Conclusions: MRI-PDFF has high diagnostic accuracy at detecting and grading LS with histology as reference standard, suggesting that MRI-PDFF is able to provide an accurate quantification of LS in clinical trials and patient care.Key Point: • MRI-PDFF is able to provide an accurate quantification of LS in clinical trials and patient care. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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