Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man.

Objective: The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylor...

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Detalles Bibliográficos
Publicado en:	European Journal of Gastroenterology & Hepatology Vol. 13; no. 1; pp. 25 - 30
Autores principales:	Felley, C P, Corthésy-Theulaz, I, Rivero, J L, Sipponen, P, Kaufmann, M, Bauerfeind, P, Wiesel, P H, Brassart, D, Pfeifer, A, Blum, A L, Michetti, P
Formato:	clinical trial research randomized controlled trial Journal Article
Publicado:	Lippincott Williams & Wilkins 2001 Jan
Acceso en línea:	Ver este registro en EBSCOhost

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Sumario:	Objective: The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylori infection.Design and Methods: Fifty-three volunteers infected with H. pylori as determined by positive 13C-urea breath test and positive serology were randomized to receive either LC-1 or a placebo 180 ml twice a day for 3 weeks. All subjects also received clarithromycin 500 mg bid during the last two weeks of acidified milk therapy. Oesophagogastroduodenoscopy and biopsies were performed at inclusion and repeated 4-8 weeks after the end of the treatment. H. pylori infection was confirmed by urease test and histology. H. pylori density and inflammation were scored using a modified Sydney classification.Results: LC-1 ingestion induced a decrease in H. pylori density in the antrum (P= 0.02) and the corpus (P= 0.04). LC-1 also reduced inflammation and gastritis activity in the antrum (P= 0.02 and P= 0.01, respectively) and of activity in the corpus (P= 0.02). Clarithromycin eradicated H. pylori in 26% of the subjects; LC-1 did not improve the antibiotic effect.Conclusion: These results suggest that H. pylori infection and gastritis can be down-regulated by LC-1.