Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man.
Objective: The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylor...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 13; no. 1; pp. 25 - 30 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | clinical trial research randomized controlled trial Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2001 Jan
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138559495&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138559495 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2001 Jan vid: 13 iid: 1 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 138559495 138559495 NLM11204805 138559495 10.1097/00042737-200101000-00005 NLM11204805 138559495 ppf: 25 ppct: 5 formats: tig: atl: Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. aug: au: Felley, C P Corthésy-Theulaz, I Rivero, J L Sipponen, P Kaufmann, M Bauerfeind, P Wiesel, P H Brassart, D Pfeifer, A Blum, A L Michetti, P affil: Division of Gastroenterology, University Hospital, Lausanne, Switzerland sug: subj: Milk Microbiology Lactobacillus Acidophilus Gastritis Microbiology Helicobacter Infections Therapy Gastritis Therapy Helicobacter Pylori Antibiotics Therapeutic Use Male Human Clarithromycin Therapeutic Use Breath Tests Female Pyloric Antrum Microbiology Animal Studies Double-Blind Studies Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Male Female ab: Objective: The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylori infection.Design and Methods: Fifty-three volunteers infected with H. pylori as determined by positive 13C-urea breath test and positive serology were randomized to receive either LC-1 or a placebo 180 ml twice a day for 3 weeks. All subjects also received clarithromycin 500 mg bid during the last two weeks of acidified milk therapy. Oesophagogastroduodenoscopy and biopsies were performed at inclusion and repeated 4-8 weeks after the end of the treatment. H. pylori infection was confirmed by urease test and histology. H. pylori density and inflammation were scored using a modified Sydney classification.Results: LC-1 ingestion induced a decrease in H. pylori density in the antrum (P= 0.02) and the corpus (P= 0.04). LC-1 also reduced inflammation and gastritis activity in the antrum (P= 0.02 and P= 0.01, respectively) and of activity in the corpus (P= 0.02). Clarithromycin eradicated H. pylori in 26% of the subjects; LC-1 did not improve the antibiotic effect.Conclusion: These results suggest that H. pylori infection and gastritis can be down-regulated by LC-1. pubtype: Academic Journal doctype: clinical trial research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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