Prognostic value of acoustic structure quantification in patients with Hashimoto's thyroiditis.
Objectives: Assessment of thyroid parenchymal echogenicity on ultrasonography is a predictor of future thyroid dysfunction. Our objective was to determine the prognostic value of acoustic structure quantification (ASQ) to predict the outcome of patients with Hashimoto's thyroiditis (HT).Materials an...
| Publicado en: | European Radiology Vol. 29; no. 11; pp. 5971 - 5981 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139163652&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139163652 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2019 vid: 29 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139163652 139163652 144096550 NLM30989347 10.1007/s00330-019-06174-z NLM30989347 139163652 ppf: 5971 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prognostic value of acoustic structure quantification in patients with Hashimoto's thyroiditis. aug: au: Lee, Ji Ye Hong, Hyun Sook Kim, Chul-Hee affil: Department of Radiology, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, 420-767, Bucheon, South Korea sug: subj: Thyroiditis, Autoimmune Hypothyroidism Male ROC Curve Aged Acoustics Adult Cox Proportional Hazards Model Ultrasonography Hypothyroidism Etiology Female Middle Age Prognosis Risk Factors Questionnaires Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objectives: Assessment of thyroid parenchymal echogenicity on ultrasonography is a predictor of future thyroid dysfunction. Our objective was to determine the prognostic value of acoustic structure quantification (ASQ) to predict the outcome of patients with Hashimoto's thyroiditis (HT).Materials and Methods: We prospectively evaluated 90 patients with HT using ASQ from May to December 2013. Surveillance for the development of overt hypothyroidism was conducted over a median period of 40 months (3-55). ASQ were dichotomized based on optimal cutoff values obtained from ROC curve analysis. The probability of developing overt hypothyroidism was compared between the dichotomized subgroups using Kaplan-Meier analysis and log-rank tests. Multivariate Cox regression analysis was performed to determine significant prognostic factors.Results: The cumulative rate of overt hypothyroidism was 67.7%. The median interval to overt hypothyroidism was 27.9 months (95% confidence interval, 12.0-38.0 months). There was no significant difference in the risk of overt hypothyroidism using qualitative echogenicity between groups (p = 0.669) according to Kaplan-Meier analysis. However, the ASQ average (p < 0.001), standard deviation (p = 0.015), and focal disturbance ratio (p < 0.001) were significantly associated with an increased risk of overt hypothyroidism. Multivariate Cox regression analysis revealed that a higher ASQ average (hazard ratio, 1.03; p = 0.03) and higher thyroid-stimulating hormone level (hazard ratio, 1.02; p = 0.02) were independent predictors of overt hypothyroidism.Conclusions: ASQ has potential as a prognostic biomarker for predicting the risk of overt hypothyroidism in patients with HT.Key Points: • ASQ provides quantitative prognostic information of thyroid parenchymal echogenicity. • ASQ parameters improved the stratification of patients who are prone to develop overt hypothyroidism in HT. • ASQ can serve as prognostic biomarker in HT. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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