Imagen de Portada
Código QR

Assessment of glycosaminoglycan content in intervertebral discs of patients with leg length discrepancy: A pilot study.

Objective: Leg length discrepancy (LLD) could be a predisposing factor for early degeneration of lumbar intervertebral discs (IVD). The purpose of this study was to elucidate the molecular effect of LLD on IVDs. Methods: IVDs of Eleven patients (25.6 ± 4.3years) with LLD (> 10 mm) and 14 control sub...

Descripción completa

Publicado en:Journal of Orthopaedics Vol. 16; no. 5; pp. 363 - 368
Autores principales: Latz, David, Frenken, Miriam, Schiffner, Erik, Knautz, Maxime, Quante, Wolfgang Alois, Windolf, Joachim, Grassmann, Jan Peter, Jungbluth, Pascal, Schleich, Christoph
Formato: diagnostic images research tables/charts Journal Article
Publicado: Professor PK Surendran Memorial Education Foundation Sep/oct2019
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Objective: Leg length discrepancy (LLD) could be a predisposing factor for early degeneration of lumbar intervertebral discs (IVD). The purpose of this study was to elucidate the molecular effect of LLD on IVDs. Methods: IVDs of Eleven patients (25.6 ± 4.3years) with LLD (> 10 mm) and 14 control subjects (23.9 ± 3.5years) were compared using a 3T-MR scanner. Morphological T2-weighted and glycosaminoglycan-chemical- exchange-saturation-transfer (gagCEST) sequences were performed. Results: No differences in morphological Pfirrmann grading were found (p > 0.05). In contrast, nucleus-pulposus-gagCEST-values of L5/S1 were significantly lower (p=0.0008). Conclusion: Our results suggest that LLD is a predisposing factor for molecular IVD alterations, which are detectable even before morphological pathologies could be found.