Assessment of glycosaminoglycan content in intervertebral discs of patients with leg length discrepancy: A pilot study.
Objective: Leg length discrepancy (LLD) could be a predisposing factor for early degeneration of lumbar intervertebral discs (IVD). The purpose of this study was to elucidate the molecular effect of LLD on IVDs. Methods: IVDs of Eleven patients (25.6 ± 4.3years) with LLD (> 10 mm) and 14 control sub...
| Publicado en: | Journal of Orthopaedics Vol. 16; no. 5; pp. 363 - 368 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Professor PK Surendran Memorial Education Foundation
Sep/oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139618917&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139618917 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25899082 1CUL jtl: Journal of Orthopaedics issn: 25899082 maglogo: N pubinfo: dt: Sep/oct2019 vid: 16 iid: 5 pid: 24594 pub: Professor PK Surendran Memorial Education Foundation artinfo: ui: 139618917 139618917 139618917 10.1016/j.jor.2019.03.014 139618917 ppf: 363 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Assessment of glycosaminoglycan content in intervertebral discs of patients with leg length discrepancy: A pilot study. aug: au: Latz, David Frenken, Miriam Schiffner, Erik Knautz, Maxime Quante, Wolfgang Alois Windolf, Joachim Grassmann, Jan Peter Jungbluth, Pascal Schleich, Christoph affil: Department of Trauma and Hand Surgery, University Hospital, Moorenstrasse 5, 40225, Düsseldorf, Germany sug: subj: Glycosaminoglycans Analysis Lumbar Vertebrae Pathology Intervertebral Disk Pathology Leg Length Inequality Complications Human Pilot Studies Adult Magnetic Resonance Imaging Methods Adult: 19-44 years ab: Objective: Leg length discrepancy (LLD) could be a predisposing factor for early degeneration of lumbar intervertebral discs (IVD). The purpose of this study was to elucidate the molecular effect of LLD on IVDs. Methods: IVDs of Eleven patients (25.6 ± 4.3years) with LLD (> 10 mm) and 14 control subjects (23.9 ± 3.5years) were compared using a 3T-MR scanner. Morphological T2-weighted and glycosaminoglycan-chemical- exchange-saturation-transfer (gagCEST) sequences were performed. Results: No differences in morphological Pfirrmann grading were found (p > 0.05). In contrast, nucleus-pulposus-gagCEST-values of L5/S1 were significantly lower (p=0.0008). Conclusion: Our results suggest that LLD is a predisposing factor for molecular IVD alterations, which are detectable even before morphological pathologies could be found. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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