In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii.
Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus , Coccidioides , Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifu...
| Publicado en: | Revista Iberoamericana de Micologia Vol. 36; no. 3; pp. 139 - 142 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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Elsevier B.V.
Jul2019
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=139707705&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 139707705 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11301406 PVP jtl: Revista Iberoamericana de Micologia issn: 11301406 maglogo: N pubinfo: dt: Jul2019 vid: 36 iid: 3 pid: 467 pub: Elsevier B.V. artinfo: ui: 139707705 10.1016/j.riam.2019.01.004 ppf: 139 ppct: 3 formats: fmt: @attributes: type: T tig: atl: In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii. aug: au: Villanueva-Lozano, Hiram Treviño-Rangel, Rogelio de J. Téllez-Marroquín, Ricardo Bonifaz, Alexandro Rojas, Olga C. Hernández-Rodríguez, Pedro A. González, Gloria M. affil: Department of Microbiology, School of Medicine, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico Infectious Diseases Service, Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez", Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico Dermatology Service & Mycology Department, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico Vice-rectory Health Sciences, Department of Basic Science, Universidad de Monterrey, Nuevo Leon, Mexico su: Antifungal agents Itraconazole Sporotrichosis Amphotericin B Drug interactions Sertraline Trichosporon sug: subj: Antifungal agents Itraconazole Sporotrichosis Amphotericin B Drug interactions Sertraline Trichosporon keyword: Esporotricosis Itraconazol Sinergia Synergy Voriconazol Voriconazole ab: Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus , Coccidioides , Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifungals. In our study we evaluate the antifungal activity of SRT, alone and in combination with itraconazole (ITC), voriconazole (VRC) and amphotericin B (AMB), against 15 clinical isolates of Sporothrix schenckii. We used the broth microdilution method as described by the CLSI to test the susceptibility to antifungals, and the checkerboard microdilution method to evaluate drug interactions. The minimum inhibitory concentration (MIC) with SRT was in the range of 4–8 μg/ml, while for AMB, VRC and ITC were 0.5–4 μg/ml, 0.5–8 μg/ml and 0.125–2 μg/ml, respectively. In addition, SRT showed synergy with ITC in one strain, mainly additivity with VRC, and indifference with AMB in others. The MIC values with SRT for the isolates studied show the potential role of this drug as an adjuvant in the treatment of sporotrichosis, especially in disseminated or complicated cases. La sertralina (SRT) es un antidepresivo que ha demostrado actividad in vitro contra Cryptococcus , Coccidioides , Trichosporon y otros hongos. La esporotricosis diseminada, aunque rara, tiene una mortalidad elevada y su tratamiento es complicado, requiriendo, a menudo, la combinación de dos o más antifúngicos. En este estudio evaluamos la actividad antifúngica de SRT, sola y en combinación con itraconazol (ITC), voriconazol (VRC) y anfotericina B (AMB), frente a 15 aislamientos clínicos de Sporothrix schenckii. Se usó la técnica de microdilución en caldo para evaluar la sensibilidad a los antifúngicos y el método de tablero de damas para las interacciones entre estos fármacos. La concentración mínima inhibitoria (CMI) de SRT estuvo en el rango de 4-8 μg/ml, mientras que para AMB, VRC e ITC fue de 0,5–4 μg/ml, 0,5–8 μg/ml y 0,125–2 μg/ml, respectivamente. La SRT mostró sinergia con ITC frente a una cepa, efecto aditivo principalmente con VRC, e indiferencia con AMB. Los valores de la CMI de SRT para los aislamientos ensayados son indicativos del potencial de este fármaco como adyuvante en el tratamiento de la esporotricosis, especialmente en casos complicados o de enfermedad diseminada. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Iberoamericana de Micologia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Iberoamericana de Micologia holder: Elsevier B.V. dt: @attributes: year: 2019 holdings: @attributes: islocal: N |
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